10 games
| Date | Site | Opp AP | Opponent | UL AP | W/L | UL | Opp | OT | Overall | Conf | Attendance | City | State | Stadium | Event |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 09/25/1948 | A | Memphis | L | 7 | 13 | 0-1 | 7,000 | Memphis | Tenn. | Crump Stadium | |||||
| 10/02/1948 | H | Saint Joseph's, Ind. | W | 20 | 0 | 1-1 | 6,000 | Louisville | Ky. | Parkway Field | |||||
| 10/08/1948 | A | Xavier | L | 26 | 47 | 1-2 | 8,000 | Cincinnati | Ohio | ||||||
| 10/16/1948 | A | Akron | W | 13 | 0 | 2-2 | 5,000 | Akron | Ohio | Rubber Bowl | |||||
| 10/23/1948 | H | Western Kentucky | W | 19 | 6 | 3-2 | 1-0 | 10,000 | Louisville | Ky. | Parkway Field | ||||
| 10/30/1948 | H | Buffalo | L | 19 | 48 | 3-3 | 1-0 | 10,000 | Louisville | Ky. | Parkway Field | ||||
| 11/06/1948 | H | Catawba | W | 33 | 21 | 4-3 | 1-0 | 6,000 | Louisville | Ky. | Parkway Field | ||||
| 11/13/1948 | A | Evansville | L | 6 | 18 | 4-4 | 1-1 | 6,000 | Evansville | Ind. | Bosse Field | ||||
| 11/20/1948 | H | Bradley | W | 31 | 14 | 5-4 | 1-1 | 7,000 | Louisville | Ky. | Parkway Field | ||||
| 11/27/1948 | A | Washington, Mo. | L | 12 | 27 | 5-5 | 1-1 | 6,000 | St. Louis | Mo. | Francis Field |