11 games
| Date | Site | Opp AP | Opponent | UL AP | W/L | UL | Opp | OT | Overall | Conf | Attendance | City | State | Stadium | Event |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 09/17/1949 | H | Saint Joseph's, Ind. | W | 33 | 7 | 1-0 | 8,000 | Louisville | Ky. | duPont Manual Stadium | |||||
| 09/24/1949 | A | Western Kentucky | W | 47 | 7 | 2-0 | 5,000 | Bowling Green | Ky. | Western Stadium | |||||
| 09/30/1949 | H | Murray State | W | 34 | 14 | 3-0 | 9,000 | Louisville | Ky. | duPont Manual Stadium | |||||
| 10/08/1949 | H | Miami, Fla. | L | 0 | 26 | 3-1 | 12,000 | Louisville | Ky. | duPont Manual Stadium | |||||
| 10/15/1949 | H | Akron | W | 62 | 6 | 4-1 | Louisville | Ky. | duPont Manual Stadium | ||||||
| 10/21/1949 | H | Xavier | L | 7 | 19 | 4-2 | Louisville | Ky. | duPont Manual Stadium | ||||||
| 10/29/1949 | A | Bradley | W | 35 | 12 | 5-2 | Peoria | Ill. | Peoria Stadium | ||||||
| 11/05/1949 | A | Catawba | W | 41 | 7 | 6-2 | 3,000 | Salisbury | N.C. | Shuford Stadium | |||||
| 11/12/1949 | H | Washington, Mo. | W | 35 | 12 | 7-2 | 9,000 | Louisville | Ky. | duPont Manual Stadium | |||||
| 11/19/1949 | H | Evansville | W | 28 | 7 | 8-2 | Louisville | Ky. | duPont Manual Stadium | ||||||
| 11/24/1949 | A | Southern Mississippi | L | 21 | 26 | 8-3 | 10,000 | Hattiesburg | Miss. |