10 games
| Date | Site | Opp AP | Opponent | UL AP | W/L | UL | Opp | OT | Overall | Conf | Attendance | City | State | Stadium | Event |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 09/15/1959 | H | Western Kentucky | W | 19 | 0 | 1-0 | 3,000 | Louisville | Ky. | Fairgrounds Stadium | |||||
| 09/19/1959 | A | Xavier | L | 13 | 28 | 1-1 | Cincinnati | Ohio | |||||||
| 09/25/1959 | A | Eastern Kentucky | W | 14 | 7 | 2-1 | 3,500 | Richmond | Ky. | Hanger Stadium | |||||
| 10/03/1959 | A | Bradley | W | 28 | 8 | 3-1 | Peoria | Ill. | Peoria Stadium | ||||||
| 10/10/1959 | A | Murray State | W | 28 | 0 | 4-1 | Murray | Ky. | Cutchin Stadium | ||||||
| 10/17/1959 | H | Dayton | W | 32 | 6 | 5-1 | Louisville | Ky. | Fairgrounds Stadium | ||||||
| 10/31/1959 | H | Marshall | W | 48 | 6 | 6-1 | 3,000 | Louisville | Ky. | Fairgrounds Stadium | |||||
| 11/07/1959 | A | North Texas | L | 7 | 39 | 6-2 | Denton | Texas | Fouts Field | ||||||
| 11/14/1959 | H | Ohio | L | 15 | 22 | 6-3 | 5,000 | Louisville | Ky. | Fairgrounds Stadium | |||||
| 11/21/1959 | A | Kent State | L | 14 | 16 | 6-4 | Kent | Ohio | Memorial Stadium |