9 games
| Date | Site | Opp AP | Opponent | UL AP | W/L | UL | Opp | OT | Overall | Conf | Attendance | City | State | Stadium | Event |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 09/16/1961 | H | Tennessee Tech | W | 29 | 13 | 1-0 | 6,148 | Louisville | Ky. | Fairgrounds Stadium | |||||
| 09/22/1961 | A | Eastern Kentucky | W | 33 | 6 | 2-0 | 4,100 | Richmond | Ky. | Hanger Stadium | |||||
| 09/30/1961 | H | Marshall | W | 32 | 7 | 3-0 | 3,126 | Louisville | Ky. | Fairgrounds Stadium | |||||
| 10/07/1961 | H | Memphis | L | 13 | 28 | 3-1 | 11,332 | Louisville | Ky. | Fairgrounds Stadium | |||||
| 10/14/1961 | H | Dayton | L | 6 | 7 | 3-2 | 4,236 | Louisville | Ky. | Fairgrounds Stadium | |||||
| 10/21/1961 | H | Western Kentucky | W | 20 | 0 | 4-2 | 4,825 | Louisville | Ky. | Fairgrounds Stadium | |||||
| 11/04/1961 | A | Xavier | L | 8 | 16 | 4-3 | 4,532 | Cincinnati | Ohio | Xavier Stadium | |||||
| 11/11/1961 | A | Kent State | W | 19 | 15 | 5-3 | 4,000 | Kent | Ohio | Memorial Stadium | |||||
| 11/18/1961 | A | North Texas | W | 20 | 0 | 6-3 | 4,000 | Denton | Texas | Fouts Field |