11 games
| Date | Site | Opp AP | Opponent | UL AP | W/L | UL | Opp | OT | Overall | Conf | Attendance | City | State | Stadium | Event |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 09/07/1985 | A | West Virginia | L | 13 | 52 | 0-1 | 62,128 | Morgantown | W.Va. | Mountaineer Field | |||||
| 09/14/1985 | A | Indiana | L | 28 | 41 | 0-2 | 37,626 | Bloomington | Ind. | Memorial Stadium | |||||
| 09/21/1985 | H | Western Kentucky | W | 23 | 14 | 1-2 | 36,914 | Louisville | Ky. | Cardinal Stadium | |||||
| 09/28/1985 | H | Houston | L | 27 | 49 | 1-3 | 30,334 | Louisville | Ky. | Cardinal Stadium | |||||
| 10/05/1985 | A | Syracuse | L | 0 | 48 | 1-4 | 26,992 | Syracuse | N.Y. | Carrier Dome | |||||
| 10/12/1985 | H | Southern Mississippi | L | 12 | 42 | 1-5 | 25,843 | Louisville | Ky. | Cardinal Stadium | |||||
| 10/19/1985 | H | Cincinnati | L | 9 | 31 | 1-6 | 21,383 | Louisville | Ky. | Cardinal Stadium | |||||
| 10/26/1985 | A | 15 | Miami, Fla. | L | 7 | 45 | 1-7 | 31,761 | Miami | Fla. | Orange Bowl | ||||
| 11/02/1985 | H | Central Florida | W | 42 | 21 | 2-7 | 21,391 | Louisville | Ky. | Cardinal Stadium | |||||
| 11/09/1985 | A | Virginia Tech | L | 17 | 41 | 2-8 | 28,300 | Blacksburg | Va. | Lane Stadium | |||||
| 11/23/1985 | H | Eastern Kentucky | L | 21 | 45 | 2-9 | 30,113 | Louisville | Ky. | Cardinal Stadium |