11 games
| Date | Site | Opp AP | Opponent | UL AP | W/L | UL | Opp | OT | Overall | Conf | Attendance | City | State | Stadium | Event |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 09/03/1988 | A | Maryland | L | 16 | 27 | 0-1 | 30,457 | College Park | Md. | Byrd Stadium | |||||
| 09/10/1988 | H | Wyoming | L | 9 | 44 | 0-2 | 29,105 | Louisville | Ky. | Cardinal Stadium | |||||
| 09/17/1988 | H | Memphis | W | 29 | 18 | 1-2 | 22,476 | Louisville | Ky. | Cardinal Stadium | |||||
| 09/24/1988 | A | North Carolina | W | 38 | 34 | 2-2 | 49,900 | Chapel Hill | N.C. | Kenan Stadium | |||||
| 10/01/1988 | A | Southern Mississippi | L | 23 | 30 | 2-3 | 17,584 | Hattiesburg | Miss. | M. M. Roberts Stadium | |||||
| 10/08/1988 | H | Tulsa | W | 9 | 3 | 3-3 | 24,381 | Louisville | Ky. | Cardinal Stadium | |||||
| 10/15/1988 | H | Virginia | W | 30 | 28 | 4-3 | 30,142 | Louisville | Ky. | Cardinal Stadium | |||||
| 10/22/1988 | A | Tulane | W | 38 | 35 | 5-3 | 24,824 | New Orleans | La. | Superdome | |||||
| 10/29/1988 | A | Cincinnati | W | 21 | 6 | 6-3 | 19,193 | Cincinnati | Ohio | Nippert Stadium | |||||
| 11/05/1988 | H | Virginia Tech | W | 13 | 3 | 7-3 | 21,107 | Louisville | Ky. | Cardinal Stadium | |||||
| 11/12/1988 | H | Western Kentucky | W | 35 | 17 | 8-3 | 31,636 | Louisville | Ky. | Cardinal Stadium |