12 games
| Date | Site | Opp AP | Opponent | UL AP | W/L | UL | Opp | OT | Overall | Conf | Attendance | City | State | Stadium | Event |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 09/01/1990 | A | San Jose State | T | 10 | 10 | 0-0-1 | 16,281 | San Jose | Calif. | Spartan Stadium | |||||
| 09/08/1990 | H | Murray State | W | 68 | 0 | 1-0-1 | 34,417 | Louisville | Ky. | Cardinal Stadium | |||||
| 09/15/1990 | H | Kansas | W | 28 | 16 | 2-0-1 | 35,848 | Louisville | Ky. | Cardinal Stadium | |||||
| 09/22/1990 | A | West Virginia | W | 9 | 7 | 3-0-1 | 61,933 | Morgantown | W.Va. | Mountaineer Field | |||||
| 09/29/1990 | A | Southern Mississippi | L | 13 | 25 | 3-1-1 | 20,545 | Hattiesburg | Miss. | M. M. Roberts Stadium | |||||
| 10/06/1990 | H | Tulsa | W | 38 | 14 | 4-1-1 | 36,692 | Louisville | Ky. | Cardinal Stadium | |||||
| 10/13/1990 | H | Memphis | W | 19 | 17 | 5-1-1 | 37,423 | Louisville | Ky. | Cardinal Stadium | |||||
| 10/20/1990 | A | Pittsburgh | W | 27 | 20 | 6-1-1 | 34,261 | Pittsburgh | Pa. | Pitt Stadium | |||||
| 10/27/1990 | H | Western Kentucky | W | 41 | 7 | 7-1-1 | 35,122 | Louisville | Ky. | Cardinal Stadium | |||||
| 11/03/1990 | A | Cincinnati | 25 | W | 41 | 16 | 8-1-1 | 23,575 | Cincinnati | Ohio | Riverfront Stadium | ||||
| 11/10/1990 | H | Boston College | 22 | W | 17 | 10 | 9-1-1 | 37,636 | Louisville | Ky. | Cardinal Stadium | ||||
| 01/01/1991 | N | 25 | Alabama | 18 | W | 34 | 7 | 10-1-1 | 69,098 | Tempe | Ariz. | Sun Devil Stadium | Fiesta Bowl |