11 games
| Date | Site | Opp AP | Opponent | UL AP | W/L | UL | Opp | OT | Overall | Conf | Attendance | City | State | Stadium | Event |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 08/31/1991 | H | Eastern Kentucky | W | 24 | 14 | 1-0 | 38,542 | Louisville | Ky. | Cardinal Stadium | |||||
| 09/05/1991 | H | 11 | Tennessee | L | 11 | 28 | 1-1 | 40,457 | Louisville | Ky. | Cardinal Stadium | ||||
| 09/14/1991 | A | 19 | Ohio State | L | 15 | 23 | 1-2 | 91,734 | Columbus | Ohio | Ohio Stadium | ||||
| 09/28/1991 | H | Southern Mississippi | W | 28 | 14 | 2-2 | 38,231 | Louisville | Ky. | Cardinal Stadium | |||||
| 10/05/1991 | H | Cincinnati | L | 7 | 30 | 2-3 | 34,327 | Louisville | Ky. | Cardinal Stadium | |||||
| 10/12/1991 | A | Boston College | L | 3 | 33 | 2-4 | 27,839 | Chestnut Hill | Mass. | Alumni Stadium | |||||
| 10/19/1991 | H | Army | L | 12 | 37 | 2-5 | 33,147 | Louisville | Ky. | Cardinal Stadium | |||||
| 10/26/1991 | A | Virginia Tech | L | 13 | 41 | 2-6 | 45,662 | Blacksburg | Va. | Lane Stadium | |||||
| 11/02/1991 | H | 1 | Florida State | L | 15 | 40 | 2-7 | 34,270 | Louisville | Ky. | Cardinal Stadium | ||||
| 11/09/1991 | A | Memphis | L | 7 | 35 | 2-8 | 16,665 | Memphis | Tenn. | Liberty Bowl Memorial Stadium | |||||
| 11/16/1991 | A | Tulsa | L | 0 | 40 | 2-9 | 31,717 | Tulsa | Okla. | Skelly Stadium |