13 games
| Date | Site | Opp AP | Opponent | UL AP | W/L | UL | Opp | OT | Overall | Conf | Attendance | City | State | Stadium | Event |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 08/31/2003 | A | Kentucky | W | 40 | 24 | 1-0 | 70,467 | Lexington | Ky. | Commonwealth Stadium | |||||
| 09/13/2003 | A | Syracuse | W | 30 | 20 | 2-0 | 38,550 | Syracuse | N.Y. | Carrier Dome | |||||
| 09/20/2003 | H | Texas-El Paso | W | 42 | 14 | 3-0 | 40,205 | Louisville | Ky. | Papa John's Cardinal Stadium | |||||
| 09/27/2003 | H | Temple | W | 21 | 12 | 4-0 | 38,489 | Louisville | Ky. | Papa John's Cardinal Stadium | |||||
| 10/04/2003 | A | South Florida | L | 28 | 31 | 2 OT | 4-1 | 0-1 | 36,044 | Tampa | Fla. | Raymond James Stadium | |||
| 10/11/2003 | H | Army | W | 34 | 10 | 5-1 | 1-1 | 40,432 | Louisville | Ky. | Papa John's Cardinal Stadium | ||||
| 10/17/2003 | H | Tulane | W | 47 | 28 | 6-1 | 2-1 | 38,119 | Louisville | Ky. | Papa John's Cardinal Stadium | ||||
| 10/25/2003 | A | East Carolina | W | 36 | 20 | 7-1 | 3-1 | 33,420 | Greenville | N.C. | Dowdy-Ficklin Stadium | ||||
| 11/05/2003 | A | 13 | Texas Christian | L | 28 | 31 | 7-2 | 3-2 | 33,681 | Fort Worth | Texas | Amon G. Carter Stadium | |||
| 11/15/2003 | H | Memphis | L | 7 | 37 | 7-3 | 3-3 | 30,114 | Louisville | Ky. | Papa John's Cardinal Stadium | ||||
| 11/22/2003 | H | Houston | W | 66 | 45 | 8-3 | 4-3 | 33,268 | Louisville | Ky. | Papa John's Cardinal Stadium | ||||
| 11/28/2003 | A | Cincinnati | W | 43 | 40 | 9-3 | 5-3 | 11,993 | Cincinnati | Ohio | Nippert Stadium | ||||
| 12/18/2003 | N | 14 | Miami, Ohio | L | 28 | 49 | 9-4 | 5-3 | 40,620 | Mobile | Ala. | Ladd Peebles Stadium | GMAC Bowl |