13 games
| Date | Site | Opp AP | Opponent | UL AP | W/L | UL | Opp | OT | Overall | Conf | Attendance | City | State | Stadium | Event |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 09/02/2012 | H | Kentucky | 25 | W | 32 | 14 | 1-0 | 55,386 | Louisville | Ky. | Papa John's Cardinal Stadium | ||||
| 09/08/2012 | H | Missouri State | 23 | W | 35 | 7 | 2-0 | 47,553 | Louisville | Ky. | Papa John's Cardinal Stadium | ||||
| 09/15/2012 | H | North Carolina | 19 | W | 39 | 34 | 3-0 | 53,334 | Louisville | Ky. | Papa John's Cardinal Stadium | ||||
| 09/22/2012 | A | Florida International | 20 | W | 28 | 21 | 4-0 | 12,318 | Miami | Fla. | FIU Stadium | ||||
| 09/29/2012 | A | Southern Mississippi | 19 | W | 21 | 17 | 5-0 | 23,492 | Hattiesburg | Miss. | M. M. Roberts Stadium | ||||
| 10/13/2012 | A | Pittsburgh | 18 | W | 45 | 35 | 6-0 | 1-0 | 42,432 | Pittsburgh | Pa. | Heinz Field | |||
| 10/20/2012 | H | South Florida | 16 | W | 27 | 25 | 7-0 | 2-0 | 50,167 | Louisville | Ky. | Papa John's Cardinal Stadium | |||
| 10/26/2012 | H | Cincinnati | 16 | W | 34 | 31 | OT | 8-0 | 3-0 | 53,271 | Louisville | Ky. | Papa John's Cardinal Stadium | ||
| 11/03/2012 | H | Temple | 12 | W | 45 | 17 | 9-0 | 4-0 | 44,609 | Louisville | Ky. | Papa John's Cardinal Stadium | |||
| 11/10/2012 | A | Syracuse | 11 | L | 26 | 45 | 9-1 | 4-1 | 40,312 | Syracuse | N.Y. | Carrier Dome | |||
| 11/24/2012 | H | Connecticut | 19 | L | 20 | 23 | 3 OT | 9-2 | 4-2 | 45,618 | Louisville | Ky. | Papa John's Cardinal Stadium | ||
| 11/29/2012 | A | Rutgers | W | 20 | 17 | 10-2 | 5-2 | 52,798 | Piscataway | N.J. | Rutgers Stadium | ||||
| 01/02/2013 | N | 4 | Florida | 22 | W | 33 | 23 | 11-2 | 5-2 | 54,178 | New Orleans | La. | Mercedes-Benz Superdome | Sugar Bowl |