13 games
| Date | Site | Opp AP | Opponent | UL AP | W/L | UL | Opp | OT | Overall | Conf | Attendance | City | State | Stadium | Event |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 09/02/2019 | H | 9 | Notre Dame | L | 17 | 35 | 0-1 | 58,187 | Louisville | Ky. | Cardinal Stadium | ||||
| 09/07/2019 | H | Eastern Kentucky | W | 42 | 0 | 1-1 | 48,808 | Louisville | Ky. | Cardinal Stadium | |||||
| 09/14/2019 | N | Western Kentucky | W | 38 | 21 | 2-1 | 22,665 | Nashville | Tenn. | Nissan Stadium | |||||
| 09/21/2019 | A | Florida State | L | 24 | 35 | 2-2 | 0-1 | 46,530 | Tallahassee | Fla. | Doak Campbell Stadium | ||||
| 10/05/2019 | H | Boston College | W | 41 | 39 | 3-2 | 1-1 | 46,007 | Louisville | Ky. | Cardinal Stadium | ||||
| 10/12/2019 | A | 19 | Wake Forest | W | 62 | 59 | 4-2 | 2-1 | 24,434 | Winston-Salem | N.C. | BB&T Field | |||
| 10/19/2019 | H | 3 | Clemson | L | 10 | 45 | 4-3 | 2-2 | 51,015 | Louisville | Ky. | Cardinal Stadium | |||
| 10/26/2019 | H | Virginia | W | 28 | 21 | 5-3 | 3-2 | 48,689 | Louisville | Ky. | Cardinal Stadium | ||||
| 11/09/2019 | A | Miami, Fla. | L | 27 | 52 | 5-4 | 3-3 | 53,111 | Miami | Fla. | Hard Rock Stadium | ||||
| 11/16/2019 | A | North Carolina State | W | 34 | 20 | 6-4 | 4-3 | 54,089 | Raleigh | N.C. | Carter-Finley Stadium | ||||
| 11/23/2019 | H | Syracuse | W | 56 | 34 | 7-4 | 5-3 | 46,769 | Louisville | Ky. | Cardinal Stadium | ||||
| 11/30/2019 | A | Kentucky | L | 13 | 45 | 7-5 | 5-3 | 48,336 | Lexington | Ky. | Kroger Field | ||||
| 12/30/2019 | N | Mississippi State | W | 38 | 28 | 8-5 | 5-3 | 46,850 | Nashville | Tenn. | Nissan Stadium | Music City Bowl |